Description

CARDULES ISMN SR 40 is a sustained-release formulation containing Isosorbide Mononitrate 40 mg, a nitrate-based compound widely used for the prevention and long-term treatment of angina pectoris (chest pain linked to coronary heart disease). The medication works by relaxing and dilating blood vessels, improving blood circulation to the heart. This reduces the heart’s workload and helps prevent episodes of chest pain, especially in patients with chronic stable angina. It is typically prescribed as part of a long-term cardiovascular management plan. Key Benefits: Effectively helps prevent and manage angina in patients with coronary artery disease. Enhances blood flow to the heart muscle, reducing the risk of ischemia. Lowers the heart’s oxygen demand by reducing both preload and afterload. Sustained-release formula ensures prolonged therapeutic action and steady drug levels. Minimizes the frequency of angina episodes, improving daily comfort and physical endurance. Mechanism of Action: The active component, Isosorbide Mononitrate, is metabolized in the body into nitric oxide, a molecule that activates guanylate cyclase. This increases the production of cyclic GMP (cGMP), which promotes relaxation of vascular smooth muscles in arteries and veins. The result is vasodilation, improving blood flow and reducing cardiac workload. The sustained-release design ensures continuous symptom control throughout the day. Dosage & Usage Instructions: Take exactly as directed by your physician. Swallow the tablet whole with water—do not chew, crush, or break it. Ideally taken once daily at the same time, with or after food. Do not discontinue abruptly without medical advice. Possible Side Effects: While generally well-tolerated, some individuals may experience: Headaches (especially during initial days of treatment) Dizziness or lightheadedness Skin flushing Nausea or vomiting Fatigue Low blood pressure Rare but serious effects include allergic reactions, irregular heartbeat, or persistent chest pain. Contact your doctor immediately if these occur. ​